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There's been no encounter to this point with the use of METROGEL-VAGINAL in pregnant sufferers. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity or teratogenicity was noticed when metronidazole was administered orally to Expecting mice at six times the encouraged human dose (based on mg/m²); however, in one tiny analyze in which the drug was administered intraperitoneally, some intrauterine deaths have been noticed. The connection of those conclusions to your drug is unidentified.
The appearance of abnormal neurologic indicators requires the prompt discontinuation of metronidazole vaginal gel therapy. Metronidazole vaginal gel ought to be administered with caution to patients with central nervous system health conditions.
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Knowledge from properly-controlled trials immediately evaluating metronidazole administered orally to metronidazole administered vaginally are usually not out there.
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